منابع مشابه
Vaccine candidate discovery for the next generation of malaria vaccines
Although epidemiological observations, IgG passive transfer studies and experimental infections in humans all support the feasibility of developing highly effective malaria vaccines, the precise antigens that induce protective immunity remain uncertain. Here, we review the methodologies applied to vaccine candidate discovery for Plasmodium falciparum malaria from the pre- to post-genomic era. P...
متن کاملImplementation of the malaria candidate vaccine RTS,S/AS01
318 www.thelancet.com Vol 387 January 23, 2016 As vaccine manufacturers tackle increasingly intractable pathogens, vaccines will be developed that show effi cacy, but that are less effi cacious than established vaccines. Consequently, regulatory and public health authorities will be faced with diffi cult decisions about whether such vaccines should be recommended for implementation and, if so, ...
متن کاملA Novel Malaria Vaccine Candidate Antigen Expressed in Tetrahymena thermophila
Development of effective malaria vaccines is hampered by the problem of producing correctly folded Plasmodium proteins for use as vaccine components. We have investigated the use of a novel ciliate expression system, Tetrahymena thermophila, as a P. falciparum vaccine antigen platform. A synthetic vaccine antigen composed of N-terminal and C-terminal regions of merozoite surface protein-1 (MSP-...
متن کاملA Review of Malaria Vaccine Candidate RTS,S/AS02A
This was extracted and made into a stand-alone file in January 2010 following a request from some malaria science colleagues to do so. This is in light of the unveiling in late 2009 by the PATH Malaria Vaccine Initiative of their new strategy for developing nextgeneration vaccines, that is vaccines that go beyond the RTS,S approach. A common theme running through the original report in 2006 was...
متن کاملEvidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA.
Pregnancy-associated malaria (PAM) is characterized by the placental sequestration of Plasmodium falciparum-infected erythrocytes (IEs) with the ability to bind to chondroitin sulfate A (CSA). VAR2CSA is a leading candidate for a pregnancy malaria vaccine, but its large size ( approximately 350 kDa) and extensive polymorphism may pose a challenge to vaccine development. In this study, rabbits w...
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ژورنال
عنوان ژورنال: Expert Review of Vaccines
سال: 2011
ISSN: 1476-0584,1744-8395
DOI: 10.1586/erv.11.57